John M. O'Keefe

This paper introduces a fully automated homecage-based novel object recognition test for assessing long-term object memory in mice and demonstrates its robustness and reproducibility across facilities.

This study shows that hippocampal theta sweeps encode goal-directed information, independent of movement or head direction, and supports their role in online spatial planning.

The paper investigates how neurons in the amygdala and piriform cortex encode social identity, valence, and unfamiliarity during social learning and interaction.

Repix enables reliable, reusable, and versatile chronic Neuropixels recordings in unrestrained animals over months, with minimal user training and high stability.

The paper identifies event-specific neurons in the basolateral amygdala of rats that persistently encode ethological stimuli and drive circuit activity post-stimulus, supporting short-term memory consolidation.

The paper shows that hippocampal place cells use vector computations to guide navigation by converging their activity towards goal locations in a maze.

The paper introduces Neuropixels 2.0, a high-density probe for long-term brain recordings, and demonstrates its stability across months in multiple labs and species.

This paper develops an ultralight head-mounted camera system for monitoring behavior and electrophysiology in freely moving mice, showing correlations between eye position, whisking, and neural activity.