Adam W. Hantman

SORDINO for Silent, Sensitive, Specific, and Artifact-Resisting fMRI in awake behaving mice

SORDINO improves fMRI in awake mice by being silent, sensitive, specific, and resistant to motion artifacts, enabling better brain activity mapping.

Synaptic dynamics are a tunable substrate sculpting neuralpopulation activity

The paper shows that synaptic dynamics shape sparse neural activity patterns in granule cells, tuning them to match learning demands.

Selective coupling and decoupling prepare distributed brain networks for skilled action

The paper shows that selective coupling and decoupling of neurons across brain networks prepare for skilled actions, with specific neural dynamics predicting action quality and performance.

Evolutionary expansion of the corticospinal system is linked to dexterity in Peromyscus mice

This study shows that forest mice have larger corticospinal tracts and greater dexterity compared to prairie mice, supporting the hypothesis that CSN number expansion enhances motor skills.

Specific connectivity optimizes learning in thalamocortical loops

The paper identifies optimal corticothalamic connectivity structures that support learning in thalamocortical loops for motor control and working memory tasks.

Motor cortical output for skilled forelimb movement is selectively distributed across projection neuron classes

The paper shows that different components of motor commands are distributed across two types of cortical projection neurons in mice.

Dynamics of the Cortico-Cerebellar Loop Fine-Tune Dexterous Movement

This study investigates the cortico-cerebellar loop in mice, showing that perturbing the pontine nuclei alters motor behavior and suggests the loop fine-tunes motor commands during skilled reaching.

Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

The paper introduces Neuropixels 2.0, a high-density probe for long-term brain recordings, and demonstrates its stability across months in multiple labs and species.

Parvalbumin+ and Npas1+ Pallidal Neurons Have Distinct Circuit Topology and Function

This study identifies distinct roles of PV+ and Npas1+ neurons in the GPe for locomotion and shows differences in their synaptic inputs from the STN in Parkinson's disease.

Cell-type specific outcome representation in primary motor cortex

The paper identifies layer-specific outcome signals in mouse motor cortex that support reinforcement learning of skilled movements.

Cerebellar-recipient motor thalamus drives behavioral context-specific movement initiation

The paper shows that cerebellar-recipient motor thalamus provides a fixed latency signal for movement initiation, which is critical for goal-directed behavior in mice.

Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity

The paper identifies Hox gene-dependent mechanisms that govern the molecular diversity and connectivity of spinocerebellar tract neurons (SCTNs) involved in proprioception.

Cortical Column and Whole Brain Imaging of Neural Circuits with Molecular Contrast and Nanoscale Resolution

The paper combines expansion and lattice light sheet microscopy to enable high-speed, nanoscale molecular imaging of neural circuits across large volumes.

Reconstruction of 1,000 projection neurons reveals new cell types and organization of long-range connectivity in the mouse brain

The paper reconstructs 1,000 projection neurons in the mouse brain, revealing new cell types and organizational principles of long-range connectivity.

Motor cortex is an input-driven dynamical system controlling dexterous movement

The paper investigates whether motor cortex activity during skilled movement is driven by local dynamics or external inputs, finding that external inputs are required throughout the movement.

Stability, affinity and chromatic variants of the glutamate sensor iGluSnFR

The paper introduces variants of the glutamate sensor iGluSnFR with improved brightness, broader concentration detection, and different emission colors for enhanced in vivo imaging.

A single spectrum of neuronal identities across thalamus

The paper constructs a transcriptomic atlas of the thalamus, revealing a single spectrum of neuronal identities that serve as molecularly-defined filters for cortical modalities.

The Transcriptional Logic of Mammalian Neuronal Diversity

The paper identifies homeobox transcription factors as key drivers of neuronal diversity through improved expression metrics and links long genes to regulatory elements and mobile elements.