A biased allosteric modulator functions as a molecular glue to induce β2AR dimerization
Jiemin Shen, Teja Peddada, Konstantin E. Komolov, Francesco De Pascali, Alexander M. Garces, Haoqing Wang, Michael T. Lerch, Jeffrey Benovic, Jun Zhi Xu, Brian K. Kobilka
The paper shows that AP-7-168 induces β2AR dimerization by acting as a molecular glue, revealing a new allosteric mechanism for GPCR modulation.
bioRxiv · Oct 21, 2025 · PreprintBiochemistry