Jun Zhi Xu

The role of intrinsically disordered domains in regulating G protein coupled receptor signaling

This study uses single-molecule imaging to show how agonist-specific dynamics in structured and disordered regions of the 2AAR regulate signaling and function.

A biased allosteric modulator functions as a molecular glue to induce β2AR dimerization

The paper shows that AP-7-168 induces β2AR dimerization by acting as a molecular glue, revealing a new allosteric mechanism for GPCR modulation.

Structure and function of an intermediate GPCR-G protein complex

The paper resolves the structure of an intermediate GPCR-G protein complex and shows it initiates nucleotide exchange without progressing to the fully activated state, providing insights into GPCR signaling complexity.

Gαs slow conformational transition upon GTP binding and a novel Gαs regulator

The paper characterizes the conformational changes in the Gαs protein upon GTP binding and identifies a novel regulator, MAGE D2, using a Bayesian integrative modeling approach.