Alexander M. Garces

This study reveals the unliganded active state of the β2-adrenergic receptor using pressure-resolved DEER and ProGuide modeling, showing pressure-dependent conformational changes and allosteric coupling.

This study uses single-molecule imaging to show how agonist-specific dynamics in structured and disordered regions of the 2AAR regulate signaling and function.

The paper shows that AP-7-168 induces β2AR dimerization by acting as a molecular glue, revealing a new allosteric mechanism for GPCR modulation.

The paper develops a high-sensitivity stopped-flow EPR system for studying millisecond protein conformational dynamics, demonstrating its use on T4 lysozyme and β2 adrenergic receptor.

This paper improves EPR sensitivity for small aqueous biological samples using optimized dielectric resonators and multi-channel cells.