Lisa M. Savage

This study shows that adolescent intermittent ethanol increases Aβ levels in the dorsal hippocampus of aged female TgF344-AD rats, suggesting early-life ethanol exposure exacerbates Aβ pathology with age.

This study shows that adolescent alcohol exposure accelerates cognitive decline in AD model rats, with sex-specific effects on neurotrophic markers and disease progression.

This study shows that inhibiting p75NTR during adolescent alcohol exposure prevents cholinergic neuronal atrophy and related behavioral deficits in rats.

This study shows that adult-born neurons maintain hippocampal cholinergic inputs and support working memory during aging by sustaining septohippocampal circuits.

This study shows that adolescent ethanol exposure reduces cholinergic markers, decreases acetylcholine release, and increases dendritic branching in the orbital frontal cortex, contributing to cognitive impairments.