Stephen M. Day

This study shows that adolescent intermittent ethanol increases Aβ levels in the dorsal hippocampus of aged female TgF344-AD rats, suggesting early-life ethanol exposure exacerbates Aβ pathology with age.

This study shows chronic ethanol exposure worsens Alzheimer's-like pathology, behavior, and metabolism in APP/PS1 mice by increasing amyloid plaques, altering brain metabolism, and affecting behavior.

This study shows that sulfonylureas reduce Alzheimer's pathology by targeting vascular KATP channels, decreasing amyloid-beta aggregation and improving vascular function in mice.

This study shows that type 2 diabetes in vervet monkeys alters cerebrospinal fluid metabolites and amyloid levels, but not plasma metabolites or AD risk profiles.