Thomas Battram

This study identifies 440 genes/proteins associated with atopic dermatitis severity through multi-omics analyses and highlights four with significant cross-evidence, including CEP85, which may contribute to severity via impaired phagocytosis.

This study combines protein and gene expression QTLs to evaluate their concordance in drug target validation, finding that 25-30% of QTL pairs show discordant effects.

The paper evaluates the WSP model for reducing confounding in epidemiological studies, finding it susceptible to collider bias from assortative mating and attenuating genetic associations for traits like height and education.

The paper estimates the proportion of phenotypic variation captured by DNA methylation markers in 400 traits and finds that most complex traits show little association with these markers, though some like smoking have moderate capture.

This study uses Mendelian randomization to investigate causal relationships between smoking-associated DNA methylation and lung function, identifying 18 CpGs with potential causal effects on FEV1.