Roxanna Korologou‐Linden

Causes and consequences of vascular dementia across the life course: Evidence from a UK Biobank phenome-wide and Mendelian randomization study

This study identifies causes and consequences of vascular dementia using polygenic risk scores, phenome-wide association, and Mendelian randomization analyses from UK Biobank data, highlighting cardiometabolic and educational factors as key modifiable risks.

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

This study investigates causal links between genetic liability to ADHD, ASD, and Alzheimer's disease using Mendelian randomization, finding limited evidence of association.

The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization

This study uses Mendelian randomization to identify causal risk factors for Alzheimer's disease, finding that education, fluid intelligence, and physical activity are likely causal, while most associations are consequences of early disease.

Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

This study uses Mendelian randomization to investigate causal relationships between cytokine concentrations and Alzheimer's disease risk, finding weak evidence of a causal effect for some cytokines.

Effects of genetic liability to Alzheimers disease on circulating metabolites across the life course

This study examines how genetic risk for Alzheimer's disease affects plasma metabolites across different ages, finding strong associations with lipid traits, particularly influenced by the APOE4 isoform.

The bidirectional causal effects of brain morphology across the life course and risk of Alzheimers disease: A cross-cohort comparison and Mendelian randomization meta-analysis

This study uses Mendelian randomization to examine bidirectional causal effects between brain morphology and Alzheimer's disease risk across different life stages.

Smoking, DNA methylation and lung function: a Mendelian randomization analysis to investigate causal relationships

This study uses Mendelian randomization to investigate causal relationships between smoking-associated DNA methylation and lung function, identifying 18 CpGs with potential causal effects on FEV1.

Education, intelligence and Alzheimer’s disease: Evidence from a multivariable two-sample Mendelian randomization study

This study uses Mendelian randomization to show education and intelligence both causally lower Alzheimer's disease risk, with intelligence having an independent effect.