Molecular BiologybioRxivPreprint
Integrated Stress Response Triggered by Excessive Glycosylation Drives Thoracic Aortic aneurysm
Antonio Rochano-Ortiz, Irene San Sebastián-Jaraba, Carmen Zamora…·Jorge Oller
This study identifies the HBP-ISR axis as a driver of thoracic aortic aneurysm in Marfan Syndrome, showing that targeting this pathway can reverse aortic dilation in mice and is associated with human TAAD.