Author

Carolina Simó

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-7140-0795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Enrique Gabandé‐RodrígueziD· 2 shared Jorge OlleriD· 2 shared Marı́a MittelbrunniD· 2 shared Virginia García‐CañasiD· 2 shared Alberto Forteza· 1 shared Álvaro Fernández-AlmeidaiD· 1 shared Amanda Leal-Zafra· 1 shared Ana Victoria Lechuga‐ViecoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Enrique Gabandé‐RodríguezORCID

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2 papers

Recent·Most cited

Butyrate extends health and lifespan in mice with mitochondrial deficiency

Enrique Gabandé‐Rodríguez, Manuel M. Gómez de las Heras, Pablo Ramírez-Ruiz de Erenchun, Carolina Simó, Virginia García‐Cañas, Naohiro Inohara, Inés Berenguer, Violeta Enriquez-Zarralanga, Álvaro Fernández-Almeida, Jorge Oller, Gonzalo Soto‐Heredero, Elisa Carrasco, Cristina Vázquez-Muñoz, Sandra Delgado-Pulido, José Ignacio Escrig-Larena, , Marı́a Mittelbrunn

This study shows that butyrate supplementation improves health and extends lifespan in mice with mitochondrial dysfunction by restoring intestinal barrier function and epigenetic marks.

Nature Communications · Mar 13, 2026Peer-reviewedMolecular Biology

Integrated Stress Response Triggered by Excessive Glycosylation Drives Thoracic Aortic aneurysm

Antonio Rochano-Ortiz, Irene San Sebastián-Jaraba, Carmen Zamora, Carolina Simó, Virginia García‐Cañas, Sacramento Martínez-Albaladejo, María José Fernandez-Gomez, Tiago Rodrigues Velho, María Jesús Ruiz-Rodríguez, Amanda Leal-Zafra, Enrique Gabandé‐Rodríguez, Sara Martı́nez-Martı́nez, Andrea Guala, Óscar González‐Lorenzo, Luis Miguel Blanco‐Colio, , Jorge Oller

This study identifies the HBP-ISR axis as a driver of thoracic aortic aneurysm in Marfan Syndrome, showing that targeting this pathway can reverse aortic dilation in mice and is associated with human TAAD.

bioRxiv · May 31, 2024 · PreprintMolecular Biology