Integrated Stress Response Triggered by Excessive Glycosylation Drives Thoracic Aortic aneurysm
Antonio Rochano-Ortiz, Irene San Sebastián-Jaraba, Carmen Zamora, Carolina Simó, Virginia García‐Cañas, Sacramento Martínez-Albaladejo, María José Fernandez-Gomez, Tiago Rodrigues Velho, María Jesús Ruiz-Rodríguez, Amanda Leal-Zafra, Enrique Gabandé‐Rodríguez, Sara Martı́nez-Martı́nez, Andrea Guala, Óscar González‐Lorenzo, Luis Miguel Blanco‐Colio, , Jorge Oller
This study identifies the HBP-ISR axis as a driver of thoracic aortic aneurysm in Marfan Syndrome, showing that targeting this pathway can reverse aortic dilation in mice and is associated with human TAAD.
bioRxiv · May 31, 2024 · PreprintMolecular Biology