Cancer BiologybioRxivPreprint
Identification of MYC synthetic lethal genes and networks
Timothy D. Martin, Mei Yuk Choi, Rupesh S. Patel…·Stephen Joseph Elledge
The paper identifies synthetic lethal genes and networks for MYC overexpression using CRISPR and shRNA screens, finding that disrupting citrate production and transport inhibits MYC-driven tumor growth.