Author
Brigham and Women's Hospital
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Mutual co-authors in cluster
3 papers
Recent·Most cited
Timothy D. Martin, Mei Yuk Choi, Julia C. McBride, Stephen Joseph Elledge
This paper identifies tissue-specific synthetic lethal dependencies driven by KRAS mutations across different cell lineages, revealing distinct genetic vulnerabilities shaped by the tissue context.
Timothy D. Martin, Emma V. Watson, Mei Yuk Choi…·Stephen Joseph Elledge
The paper describes a method to control CRISPR/Cas9 activity using proteasomal degradation of an anti-CRISPR protein fused to a degradation or shutoff tag.
Timothy D. Martin, Mei Yuk Choi, Rupesh S. Patel…·Stephen Joseph Elledge
The paper identifies synthetic lethal genes and networks for MYC overexpression using CRISPR and shRNA screens, finding that disrupting citrate production and transport inhibits MYC-driven tumor growth.