Author

Melvys Valledor

University of Massachusetts Chan Medical SchoolORCID 0000-0001-5823-6858Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Jeanne Bentley LawrenceiD· 1 shared Kelly Smith· 1 shared Lucas Javier SosaiD· 1 shared Paul C. Schiller· 1 shared Richard S. MyersiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 4 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperDevelopmental Biology

Jeanne Bentley LawrenceORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Developmental BiologybioRxivPreprintAug 6, 2026

APP Dosage and Extracellular Domain Variants Drive Distinct Defects in Neurogenesis modeled in Down Syndrome iPS cells

Melvys Valledor, Kelly Smith, Jeanne Bentley Lawrence, Lucas Javier Sosa

This study investigates how APP dosage and extracellular domain variants affect neurogenesis in Down Syndrome iPSCs, finding distinct defects in terminal differentiation and neurite outgrowth.

DOI 10.64898/2026.08.05.742240

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyPLoS ONEPeer-reviewedAug 15, 2018

Herpes ICP8 protein stimulates homologous recombination in human cells

Melvys Valledor, Richard S. Myers, Paul C. Schiller

The paper demonstrates that Herpes ICP8 protein enhances gene targeting in human cells via homologous recombination, unlike the bacterial Beta protein which inhibits it.

9 citations

humanexperimental assay

𝕏 PostBluesky