Jeanne Bentley Lawrence

This study investigates how APP dosage and extracellular domain variants affect neurogenesis in Down Syndrome iPSCs, finding distinct defects in terminal differentiation and neurite outgrowth.

The paper describes a method to achieve high-efficiency targeted transgene integration in zygotes, producing non-mosaic transgenic animals without requiring mosaic breeding.

This study silences the extra chromosome 21 in patient-derived iPSCs to reveal cell-autonomous deficits in angiogenesis and early Notch signaling dysregulation in Down syndrome.

This study uses isogenic cerebral organoids to examine transcriptomic and cell-type differences between trisomic and disomic iPSC lines, finding that Trisomy 21 correlates with increased Aβ-40 levels but not other non-chr21 DEGs.