Author

Sornakala Ganeshkumar

University of Kansas Medical CenterORCID 0000-0001-5840-5818Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Sumedha GunewardenaiD· 3 shared Vargheese M. ChennathukuzhiiD· 3 shared Emily RobertsiD· 2 shared Aishwarya V. BhurkeiD· 1 shared Ashley S. CloudiD· 1 shared Ripla AroraiD· 1 shared Skylar G. BirdiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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3 shared papersPhysiology

Sumedha GunewardenaORCID

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3 papers

Recent·Most cited

Cell BiologyJournal of Biological ChemistryPeer-reviewedDec 9, 2025

Regulatory Role for Tumor Suppressor REST on Estrogen Receptor (ESR1) Expression and Leiomyoma Pathophysiology

Skylar G. Bird, Sumedha Gunewardena, Ashley S. Cloud…·Vargheese M. Chennathukuzhi

This study identifies REST as a regulator of ESR1 expression and highlights its role in leiomyoma pathophysiology through epigenetic mechanisms.

DOI 10.1016/j.jbc.2025.111017

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PhysiologyPNAS NexusPeer-reviewedJan 24, 2025

Loss of PRICKLE1 leads to abnormal endometrial epithelial architecture, decreased embryo implantation, and reduced fertility in mice.

Emily Roberts, Aishwarya V. Bhurke, Sornakala Ganeshkumar…·Vargheese M. Chennathukuzhi

This study shows that loss of PRICKLE1 in mouse endometrial epithelium causes abnormal architecture, reduced implantation, and infertility by disrupting cell polarity, cytokinesis, and epithelial-mesenchymal transition.

3 citations

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PhysiologyReproductionPeer-reviewedDec 16, 2024

Loss of PRICKLE1 in the myometrium leads to reduced fertility, abnormal myometrial architecture, and aberrant extracellular matrix deposition in mice.

Emily Roberts, Sornakala Ganeshkumar, Sumedha Gunewardena, Vargheese M. Chennathukuzhi

This study shows that loss of Prickle1 in mouse myometrium causes uterine leiomyoma-like features, including altered collagen, ECM deposition, and Wnt/PCP signaling disruption.

1 citation

mouseexperimental assay

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