Sumedha Gunewardena

This study shows pirfenidone reduces fibrosis and improves kidney function in ADPKD by targeting myofibroblast activation and ECM production.

This study shows REST is reduced in endometriosis and its deletion in mice causes progesterone resistance, subfertility, and larger endometriotic lesions.

This study identifies REST as a regulator of ESR1 expression and highlights its role in leiomyoma pathophysiology through epigenetic mechanisms.

This study shows that modulating β-Catenin in macrophages increases WNT expression, and WNT-enriched EVs from these macrophages reduce intestinal injury.

This study shows that Notch3 deletion reduces HIV-1 gene expression and systemic inflammation, improving outcomes in HIV-associated chronic kidney disease.

This study shows that loss of PRICKLE1 in mouse endometrial epithelium causes abnormal architecture, reduced implantation, and infertility by disrupting cell polarity, cytokinesis, and epithelial-mesenchymal transition.

This study shows that loss of Prickle1 in mouse myometrium causes uterine leiomyoma-like features, including altered collagen, ECM deposition, and Wnt/PCP signaling disruption.

This study identifies a mechanism by which estrogen receptor alpha suppresses PRICKLE1, leading to REST loss and promoting uterine fibroid development.

The paper shows that parietal trophoblast giant cells regulate hematopoietic stem cell development in the placenta through paracrine signaling.

This study identifies WWTR1 as a master regulator of human trophoblast progenitor self-renewal and differentiation, showing its role in promoting EVT differentiation and preventing STB fate.

This study uses single-cell RNA-seq to analyze age-related changes in mouse ovarian microenvironment metabolism, identifying HIF1A's role in modulating glycolysis and other metabolic pathways.

The paper identifies meiotic inhibitors in mouse and human spermatogenesis through integrative snATAC-seq and scRNA-seq analysis, showing their repression by STRA8 is critical for meiotic initiation.

This study identifies PKCλ/ι as essential for trophoblast progenitor differentiation into syncytiotrophoblast cells during placentation in both mice and humans.

Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation.

This study shows that GATA2 and GATA3 in trophoblast giant cells regulate hematopoietic-angiogenic balance in the placenta through paracrine signaling.

This study identifies that ADAR1-mediated A-to-I RNA editing in mouse oocytes preferentially targets the wobble position of codons, altering codon usage and potentially affecting mRNA stability and translation efficiency.