ImmunologyCell Death and DifferentiationPeer-reviewed
E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation
Mingyang Cheng, Yiyuan Lu, Jiarui Wang…·Yan Zeng
This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.
19 citations