Davide Piccolo

This study develops a mouse model of rhodopsin sector RP and shows that dim red light and S1PR agonist treatment can prevent light-induced photoreceptor degeneration.

This study identifies small molecules that enhance ABCA4 misfolding variant trafficking to the plasma membrane using an in vitro platform.

This study demonstrates that antisense oligonucleotides can correct splicing defects in the ABCA4 c.5461-10T>C variant, restoring protein function in retinal organoids.