Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population
Moeen Riaz, Aamira J. Huq, Joanne L. Ryan…·Paul A Lacaze
This study examines the effect of APOE genotypes and polygenic risk scores on dementia and cognitive decline in a longitudinal cohort of healthy older individuals, finding increased risks for APOE ε4 carriers and high PRS tertiles.