Ian H. Harding

A Core Pattern of Cerebellar and Brainstem Degeneration and Reduced Cerebrocerebellar Structural Covariance in Spinocerebellar Ataxia Type 3 (SCA3): MRI Volumetrics from ENIGMA-Ataxia

This study uses MRI volumetrics to analyze cerebellar and brainstem degeneration in SCA3, finding consistent atrophy patterns and reduced cerebrocerebellar covariance.

The genetic architecture of MRI derived human cervical spinal cord morphology reveals sensory-motor axis and biomarkers of neurological and systemic diseases

This study identifies genetic variants associated with cervical spinal cord morphology and links them to neurological and systemic diseases.

Factor Analysis of Multimodal MRI, Biofluid and Vascular Health Biomarkers Reveals Latent Constructs of Brain Health

The paper uses factor analysis on multimodal biomarkers to identify latent constructs of brain health, finding five distinct constructs associated with age and cognitive function.

Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study

This study examines relationships between MRI-based measures of neurovascular integrity and fluid transport in older adults, finding age-related changes and stable inter-relationships among these metrics.

Plasma pTau-217 Correlates with Brain Atrophy, Cognition, and CSF Biomarkers in a Cognitively Healthy Community Cohort

This study finds plasma pTau-217 correlates with cognition and brain atrophy in cognitively healthy older adults and strongly correlates with its CSF counterpart.

The Pattern and Staging of Brain Atrophy in Spinocerebellar Ataxia Type 2 (SCA2): MRI Volumetrics from ENIGMA-Ataxia

This study uses MRI volumetrics to characterize brain atrophy patterns in SCA2, finding progressive degeneration starting in cerebellar white matter and spreading to other brain regions.

Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study

This study identifies subregional cerebellar atrophy patterns in epilepsy syndromes using MRI data from 1,602 patients and 1,022 controls, finding significant volume loss in posterior lobe regions.

Hypothalamic effective connectivity at rest is associated with body weight and energy homeostasis

This study examines how body weight and energy homeostasis affect effective connectivity between hypothalamic regions using resting-state fMRI in humans.

Neural network modelling reveals changes in directional connectivity between cortical and hypothalamic regions in obesity

The paper uses neural network modeling to show increased top-down excitation from the insula to the hypothalamus and reduced prefrontal cortex excitation in obesity, regardless of hunger state.

Longitudinal dentate nuclei iron concentration and atrophy in Friedreich ataxia: IMAGE-FRDA

This study tracks iron concentration and atrophy in dentate nuclei of Friedreich ataxia patients over two years, finding increased iron accumulation and stage-dependent changes.