Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population
Moeen Riaz, Aamira J. Huq, Joanne L. Ryan, Suzanne Gaye Orchard, Jane M. Tiller, Jessica E. Lockery, Robyn L. Woods, Rory S Wolfe, Alan Edward Renton, Alison Goate, Robert Sebra, Eric E. Schadt, Amy G. Brodtmann, Raj C. Shah, Elsdon Storey, , Paul A Lacaze
This study examines the effect of APOE genotypes and polygenic risk scores on dementia and cognitive decline in a longitudinal cohort of healthy older individuals, finding increased risks for APOE ε4 carriers and high PRS tertiles.
Aging Cell · May 26, 2021Peer-reviewedGenetic & Genomic Medicine