Author

Raquel A. C. Machado

University of TorontoORCID 0000-0001-5912-2991Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Aiping DongiD· 2 shared Aliakbar Khalili Yazdi· 2 shared C. H. ArrowsmithiD· 2 shared Dalia Barsyte-LovejoyiD· 2 shared Matthieu SchapiraiD· 2 shared P. LoppnauiD· 2 shared A. M. EdwardsiD· 1 shared Albina Bolotokova· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Aiping DongORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Medicinal ChemistryPeer-reviewedNov 4, 2024

A resource to enable chemical biology and drug discovery of WDR Proteins

Suzanne Z. Ackloo, Fengling Li, Magda Szewczyk…·C. H. Arrowsmith

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

28 citations

humanprotein structure

𝕏 PostBluesky

Molecular BiologyNature Chemical BiologyPeer-reviewedMay 21, 2024

A chemical probe to modulate human GID4 Pro/N-degron interactions

Dominic D. G. Owens, Matthew E. R. Maitland, Aliakbar Khalili Yazdi…·C.H. Arrowsmith

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

41 citationstop 3%

humanproteomics

𝕏 PostBluesky