Author
University of Toronto
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Suzanne Z. Ackloo, Fengling Li, Magda Szewczyk…·C. H. Arrowsmith
The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.
Dominic D. G. Owens, Matthew E. R. Maitland, Aliakbar Khalili Yazdi…·C.H. Arrowsmith
The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.
Aliakbar Khalili Yazdi, Sumera Perveen, Dong Cheng…·Dafydd R. Owen
The paper develops chemical tools and probes for the Gid4 subunit of the human CTLH E3 ligase complex, achieving sub-100 nM binding affinity for further study.