Author

Ryan C. Vignogna

Cornell UniversityORCID 0000-0001-5943-6464Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Christopher FrommeiD· 2 shared J. Ryan FeathersiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

2 top collaborators · 1 mutual co-author link

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

J. Christopher FrommeORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cell BiologyThe Journal of Cell BiologyPeer-reviewedAug 13, 2026

Avl9 defines a family of GTPase-activating proteins that regulate diverse cell biological functions

Ryan C. Vignogna, J. Christopher Fromme

This study identifies Avl9 as a GTPase-activating protein for Arf1, showing its role in secretion and cell migration and suggesting other DENN domain proteins may also function as GAPs.

DOI 10.1083/jcb.202601003

humanproteomics

𝕏 PostBluesky

Cell BiologyNature CommunicationsPeer-reviewedDec 4, 2024

Structural basis for Rab6 activation by the Ric1-Rgp1 complex

J. Ryan Feathers, Ryan C. Vignogna, J. Christopher Fromme

The paper determines the cryoEM structure of the Ric1-Rgp1-Rab6 complex, revealing its mechanism for Rab6 activation and identifying a novel RabGEF domain and arrestin fold interactions.

7 citations

cryo-EMexperimental assay

𝕏 PostBluesky