Author
Princeton UniversityORCID 0000-0002-4402-4659Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
J. Ryan Feathers, Robert C. Heeter, Geoffrey Woollard, Sonya M. Hanson, Pilar Cossio, Joel Greer, B. Tom Burnley, Ellen D. Zhong
The paper introduces the CAHRA Challenge, a community-wide assessment of cryo-EM heterogeneous reconstruction algorithms using three benchmark datasets.
bioRxiv · Oct 10, 2026 · PreprintBiophysics
Miro A. Astore, Geoffrey Woollard, David Silva-Sánchez, Wenda Zhou, Mykhailo Kopylov, Khanh Dao Duc, Roy R. Lederman, Yilai Li, Yi Zhou, Jing Yuan, Fei Ye, Quanquan Gu, Rémi Vuillemot, Slavica Jonić, Lan Dang, , Sonya M. Hanson
The paper presents a cryo-EM conformational heterogeneity challenge to evaluate and improve methods for analyzing molecular motions in heterogeneous samples.
bioRxiv · Jul 18, 2025 · PreprintBiophysics
Axel Levy, Rishwanth Raghu, J. Ryan Feathers, Michal R. Grzadkowski, Frédéric Poitevin, Jake D. Johnston, Francesca Vallese, Oliver B. Clarke, Gordon Wetzstein, Ellen D. Zhong
The paper introduces cryoDRGN-AI, a method for ab initio 3D reconstruction of cryo-EM and cryo-ET datasets, revealing new conformational states and unresolved motions.
Nature Methods · Jun 26, 2025Peer-reviewedBiophysics
J. Ryan Feathers, Ryan C. Vignogna, J. Christopher Fromme
The paper determines the cryoEM structure of the Ric1-Rgp1-Rab6 complex, revealing its mechanism for Rab6 activation and identifying a novel RabGEF domain and arrestin fold interactions.
Nature Communications · Dec 4, 2024Peer-reviewedCell Biology
Martin Obr, Clifton L. Ricana, Nadia Nikulin, J. Ryan Feathers, Marco Klanschnig, A. Thader, Marc C. Johnson, Volker M. Vogt, Florian K. M. Schur, Robert A. Dick
The paper investigates the role of IP6 in RSV capsid assembly, showing it promotes hexamer formation and is critical for infectivity.
Nature Communications · May 28, 2021Peer-reviewedMolecular Biology