Robert J. Barrett

This study compares hiPSC-derived intestinal epithelial cells cultured in organoids, Transwells, and intestine-on-chip systems, showing that the latter promotes stronger gene expression related to nutrient and drug metabolism and a more mature state.

This study shows that TL1A overexpression in Crohn's Disease and mice causes Paneth cell dysfunction and microbiota changes that promote ileal inflammation.

This paper develops a hiPSC-derived intestine-on-chip system that mimics the human small intestine's epithelial, mesenchymal, and neural composition and function.