Author

Eline Smits

University Medical Center GroningenORCID 0009-0004-2116-5231Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Aarón D. Ramírez-SáncheziD· 2 shared Cisca WijmengaiD· 2 shared Iris H. JonkersiD· 2 shared Joram MooiweeriD· 2 shared Renée MoerkensiD· 2 shared Rutger Modderman· 2 shared Sebo WithoffiD· 2 shared Cayetano Pleguezuelos‐ManzanoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersImmunology

Aarón D. Ramírez-SánchezORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Autologous biopsy-derived co-culture platform for interrogation of intestinal epithelial-T cell crosstalk

Joram Mooiweer, Sajid Anwar, Nathan Vinícius Ribeiro, Aarón D. Ramírez-Sánchez, Hanna L. Simpson, Eline Smits, Renée Moerkens, Jody Gelderloos-Arends, Rutger Modderman, Gieneke Gonera-de Jong, Margreet M. S. Wessels, Cisca Wijmenga, Sebo Withoff, Iris H. Jonkers

This paper develops an autologous co-culture system to study human intestinal IEL-epithelial interactions, showing both non-destructive and cytotoxic responses under different conditions.

bioRxiv · Aug 7, 2026 · PreprintImmunology

Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

Renée Moerkens, Joram Mooiweer, Eline Smits, Marijn Berg, Aarón D. Ramírez-Sánchez, Rutger Modderman, Jens Puschhof, Cayetano Pleguezuelos‐Manzano, Robert J. Barrett, Cisca Wijmenga, Iris H. Jonkers, Sebo Withoff

This study compares hiPSC-derived intestinal epithelial cells cultured in organoids, Transwells, and intestine-on-chip systems, showing that the latter promotes stronger gene expression related to nutrient and drug metabolism and a more mature state.

Stem Cell Reports · Nov 13, 2025Peer-reviewedCell Biology