BiochemistryBiomedicine & PharmacotherapyPeer-reviewed
Restoring Cholesterol Efflux in Vascular Smooth Muscle Cells Transitioning into Foam Cells Through Liver X Receptor Activation
Carla Borràs, Noemí Rotllán, Raquel Griñán…·Joan Carles Escolá‐Gil
This study shows that activating LXR enhances cholesterol efflux from vascular smooth muscle cells (VSMCs) transitioning into foam cells, improving reverse cholesterol transport to feces and suggesting LXR agonists and ACAT inhibitors as potential therapies for atherosclerosis.