Sabrina Chau

This study identifies Nuc1, a mitochondrial enzyme, as a regulator of an RNA surveillance system in yeast that limits replication of the L-A mycovirus.

The paper identifies Por1 as a mitochondrial protein that represses Snf1/AMP Kinase signaling to limit L-A mycovirus replication in yeast.

This study shows that budding yeast uses a mitochondrial endonuclease homologue to attenuate a cytosolic virus during meiosis, revealing an ancestral role for apoptotic pathways in viral defense.