Carmen Ruiz de Almodóvar

This study identifies endolysosomal dysfunction in radial glia progenitor cells as a cause of defective cerebral angiogenesis and BBB compromise in zebrafish, linking Notch3 processing defects to CSVD phenotypes.

This study shows that Caspase-8 promotes angiogenesis in endothelial cells through a cell death-independent mechanism involving p38 MAPK activation and VE-cadherin destabilization.