Hellmut G. Augustin

This study identifies a sex-specific mechanism where platelet C5aR1 mediates ischemia-driven revascularization through estradiol-dependent CXCL4 release, explaining sex differences in cardiovascular outcomes.

This study shows that platelet C5aR1 worsens myocardial infarction by promoting neutrophil activation and NET release, and that targeting it can reduce cardiac damage.

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.

This study identifies riboflavin as a modulator of ferroptosis sensitivity by supporting FSP1 stability and antioxidant recycling, with implications for therapeutic targeting.

This study shows that Dnmt3a regulates placental vascularization and fetal growth by controlling DNA methylation in endothelial cells, identifying it as a key factor in placental function.

This study shows that Caspase-8 promotes angiogenesis in endothelial cells through a cell death-independent mechanism involving p38 MAPK activation and VE-cadherin destabilization.