Author
Richard O. C. Oreffo
University of SouthamptonORCID 0000-0001-5995-6726Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 16 mutual co-author links6 papers
Recent·Most cited
- BioengineeringActa BiomaterialiaPeer-reviewed
Localized Delivery of Growth Factors from Microparticles Modulate Osteogenic and Chondrogenic Gene Expression in Growth Factor-dependent Manner in an ex vivo Chick Embryonic Bone Model.
Hassan Rashidi, Helen C. Cox, Omar Qutachi…·Felicity R. A. J. Rose
The paper develops an ex vivo chick embryonic bone model using PLGA microparticles to study growth factor delivery effects on cell differentiation and tissue formation, showing that controlled release of BMP2 and FGF2 alters collagen deposition and cell morphology.
- Cancer BiologybioRxivPreprint
Characterising Type I Collagen Architecture in Human Bone and Osteosarcoma with Second Harmonic Generation Microscopy
Belle Creith, James Harrison, Peter Johnson…·Sumeet Mahajan
This paper uses SHG microscopy to quantify collagen fibre-length differences in human bone and osteosarcoma, showing reduced fibre lengths in OS compared to normal bone.
- BioengineeringbioRxivPreprint
Novel Biomolecular techniques in the analysis of Orthopaedic trabecular metal implants produced by additive manufacturing
Jack Hurst, Richard O. C. Oreffo, D. Dunlop
The paper develops novel biomolecular techniques to image and analyze orthopaedic trabecular metal implants, showing varying responses of human bone marrow stem cells to different implant designs.
- BioengineeringBiomaterials AdvancesPeer-reviewed
Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite(R) to deliver BMP-2 in an ovine femoral condyle defect model
Karen M. Marshall, Jane S. McLaren, Jonathan P. Wojciechowski…·Richard O. C. Oreffo
This study evaluates Laponite(R)-coated scaffolds for delivering BMP-2 in a large animal bone defect model, showing enhanced bone formation compared to uncoated scaffolds.
- Systems BiologybioRxivPreprint
Mapping biology from mouse to man using transfer learning
Patrick S. Stumpf, Xin Du, Haruka Imanishi…·Ben D. MacArthur
This paper uses transfer learning to map biology from mouse to human bone marrow using single-cell RNA-sequencing data, showing improved accuracy with retraining and zero-shot learning.