Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis
Michaela O. Lunn, Karan Thakur, Nathalie A. Lengacher, Quinton Hake-Volling, aSCENT-PD Investigators, Julianna J. Tomlinson, Subash Sad, Earl G. Brown, Michael G. Schlossmacher
This study shows that Lrrk2 p.G2019S mutant mice exhibit increased phosphorylated α-synuclein and tau in the brain after influenza A infection, suggesting a link between LRRK2 mutations and neurodegeneration.
bioRxiv · Jul 31, 2025 · PreprintNeuroscience