Author

aSCENT-PD Investigators

University of Ottawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Earl G. BrowniD· 2 shared Julianna J. TomlinsoniD· 2 shared Michael G. SchlossmacheriD· 2 shared A.-K. Jochum· 1 shared Alexandra R GarzaiD· 1 shared Alp ÖzgüniD· 1 shared Anthony M InsalacoiD· 1 shared Benjamin D. W. BelfortiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Earl G. BrownORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis

Michaela O. Lunn, Karan Thakur, Nathalie A. Lengacher, Quinton Hake-Volling, aSCENT-PD Investigators, Julianna J. Tomlinson, Subash Sad, Earl G. Brown, Michael G. Schlossmacher

This study shows that Lrrk2 p.G2019S mutant mice exhibit increased phosphorylated α-synuclein and tau in the brain after influenza A infection, suggesting a link between LRRK2 mutations and neurodegeneration.

bioRxiv · Jul 31, 2025 · PreprintNeuroscience

Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons

Benjamin D. W. Belfort, Johnathan D. Jia, Alexandra R Garza, Anthony M Insalaco, John P. McGinnis, Brandon T. Pekarek, Joshua Ortiz‐Guzman, Burak Tepe, Hu Chen, aSCENT-PD Investigators, Zhandong Liu, Benjamin Russell Arenkiel

This study compares 11 AAV serotypes for transduction efficiency and specificity in murine olfactory sensory neurons using nasal inoculation.

Frontiers in Neuroscience · Feb 13, 2025Peer-reviewedNeuroscience

A Protocol for Neuralized Murine Olfactory Organoids

Alp Özgün, Priya Suman, Josée Coulombe, aSCENT-PD Investigators, Earl G. Brown, Julianna J. Tomlinson, John Woulfe, Michael G. Schlossmacher

This paper presents a method to generate olfactory organoids from adult mice to study environmental interactions with the olfactory epithelium and disease processes.

bioRxiv · Oct 29, 2024 · PreprintNeuroscience

Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19

N. A. Lengacher, J. J. Tomlinson, A.-K. Jochum, J. Franz, O. Hasan Ali, L. Flatz, W. Jochum, J. Penninger, aSCENT-PD Investigators, C. Stadelmann-Nessler, J. M. Woulfe, M. G. Schlossmacher

This study examines neuropathological changes in the olfactory bulb and tract of COVID-19 patients, finding no significant inflammation but age-related decline in anti-CD68 reactivity and mild increases in phospho-Syn and phospho-tau signals in affected brains.

bioRxiv · Dec 18, 2023Pathology