Epistasis between drug resistance-conferring mutations in Mycobacterium tuberculosis
Selim Bouaouina, Sònia Borrell, Jérôme Azizaj…·Sébastien Gagneux
The paper shows that epistatic interactions between RpoB and GyrA mutations in Mycobacterium tuberculosis can lead to high-fitness double-resistant strains, which are prevalent in clinical isolates.