Zhi Ming Xu

The paper identifies genetic pathways and variants associated with sepsis susceptibility in children through genomic analysis of a paediatric cohort.

This paper identifies a genetic locus associated with sepsis susceptibility in children using a genome-wide association study of a national cohort.

This study examines the relationship between human genetic ancestry, Mycobacterium tuberculosis diversity, and TB disease severity in Dar es Salaam, Tanzania, finding no significant genetic influence on disease severity.

The study infects macrophages from tuberculosis patients with different MTBC lineages to show that bacterial phylogenetic diversity, not local adaptation, drives variable macrophage responses.

This study identifies high polygenic risk and infection with Fusobacterium nucleatum as independent risk factors for incident coronary heart disease in a population cohort.

G2GSnake provides a Snakemake workflow and R Shiny app for reproducible genome-to-genome association studies between host and pathogen genomes.

The paper improves genotype imputation in underrepresented populations by adding population-specific SNPs to existing reference panels, showing improved accuracy in a Tanzanian cohort.

The paper develops a polygenic response score to identify subgroups with different treatment effects by testing gene-gene interactions using pharmacomimetic genetic variants.