Author

Jonathan R. Bowles

University of ManchesterORCID 0000-0001-6042-8541Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Caroline HoppeiD· 2 shared Hilary L. AsheiD· 2 shared Magnus RattrayiD· 2 shared Catherine SutcliffeiD· 1 shared Priyanka UpadhyaiiD· 1 shared Thomas George MinchingtoniD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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2 shared papersBioinformatics

Caroline HoppeORCID

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2 papers

Recent·Most cited

BioinformaticsBioinformaticsPeer-reviewedNov 5, 2021

Scalable inference of transcriptional kinetic parameters from MS2 time series data

Jonathan R. Bowles, Caroline Hoppe, Hilary L. Ashe, Magnus Rattray

The paper introduces a scalable method to infer transcriptional kinetic parameters from MS2-McP time series data, enabling efficient analysis of promoter activity in Drosophila embryos.

12 citations

Drosophilaimaging

𝕏 PostBluesky

Developmental BiologyDevelopmental CellPeer-reviewedAug 5, 2020

Modulation of the promoter activation rate dictates the transcriptional response to graded BMP signaling levels in the Drosophila embryo

Caroline Hoppe, Jonathan R. Bowles, Thomas George Minchington…·Hilary L. Ashe

The paper shows that BMP signaling modulates transcriptional burst frequency by altering promoter activation rate in Drosophila embryos, leading to graded mRNA output across expression domains.

69 citations

Drosophilastatistical model

𝕏 PostBluesky