Thomas George Minchington

Fabrication of elastomeric stencils for patterned stem cell differentiation

This paper describes a method to create elastomeric stencils for controlled stem cell differentiation and pattern formation.

Self-organised pattern formation in the developing neural tube by a temporal relay of BMP signalling

The paper studies BMP signalling dynamics in the developing neural tube, showing temporal relay mechanisms drive self-organised cell type patterns.

Dynamics of hunchback translation in real time and at single mRNA resolution in the Drosophila embryo

The paper uses the SunTag system to study zygotic hb mRNA translation dynamics in Drosophila embryos, showing translational repression and spatial restriction over time.

Modulation of the promoter activation rate dictates the transcriptional response to graded BMP signaling levels in the Drosophila embryo

The paper shows that BMP signaling modulates transcriptional burst frequency by altering promoter activation rate in Drosophila embryos, leading to graded mRNA output across expression domains.

Timing of neurogenesis through sequential accumulation of miR-9 due to additive expression of multiple alleles

The paper shows that miR-9 levels increase stepwise during zebrafish neurogenesis through sequential activation of distinct pri-mir-9 loci, which helps overcome adaptation in Her6 dynamics.

Dynamical gene regulatory networks are tuned by transcriptionalautoregulation with microRNA feedback.

The paper identifies autoregulatory and dual feedback gene network motifs in human tissues, showing their prevalence and conservation, suggesting they drive dynamical gene expression.