Author
University of California, San FranciscoORCID 0000-0001-6045-9698Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Manning Y. Huang, Patrick Hecht, Kyle Cesar…·Hiten D. Madhani
This study identifies therapeutic vulnerabilities in Cryptococcus neoformans using CRISPR-insert and machine learning, revealing new drug targets and synthetic lethal dependencies.
Matthew J. Nalley, Sanjita Banerjee, Manning Y. Huang, Hiten D. Madhani
The paper describes a high-efficiency method for homology-dependent genome editing in Cryptococcus neoformans using CRISPR/Cas9 and a Ku80 mutant strain.
Manning Y. Huang, Matthew J. Nalley, Patrick C Hecht, Hiten D. Madhani
The paper describes an optimized auxin-inducible degron system for conditional protein degradation in Cryptococcus neoformans, enabling the study of essential genes.
Michael J. Boucher, Sanjita Banerjee, Meenakshi B Joshi…·Hiten D. Madhani
The paper characterizes the phenotypic landscape of Cryptococcus neoformans by analyzing gene deletions and their fitness under various conditions, revealing novel biological insights.