Temporary deterioration of health and behavior during pexidartinib-mediated microglia depletion and repopulation in progranulin-deficient mice
Marc-Philipp Weyer, Lisa Hahnefeld, Luisa Franck…·Irmgard Tegeder
This study shows that microglia depletion in progranulin-deficient mice causes temporary health and behavioral deterioration, with lasting proinflammatory effects in the brain.