Florian olde Heuvel

Loss of C3 and CD14 reduces region-specific neuroinflammation in a murine polytrauma model

This study shows that loss of C3 and CD14 reduces neuroinflammation in a murine polytrauma model, with differential effects across brain regions.

Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice

This study shows that β-adrenergic receptors regulate spinal motoneuron excitability through homeostatic feedback in both wild-type and presymptomatic SOD1 mice.

Basophils activate splenic B cells and Dendritic cells via IL-13 signaling in acute Traumatic Brain Injury

The paper identifies basophil recruitment to the spleen following TBI and shows their activation of B cells and dendritic cells via IL-13 signaling, enhancing protein translation through NORAD.

Intracranial hypertension drives astrocyte-mediated neuroinflammation through Piezo1-dependent EGFR activation

This study identifies a mechanosensitive astrocyte signaling pathway linking intracranial pressure to neuroinflammation via Piezo1-dependent EGFR activation.

The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI

This study shows that FGFR inhibition with Rogaratinib reduces microglia reactivity and synaptic loss in TBI by dampening neuroimmunological responses.

Met/HGFR triggers detrimental reactive microglia in TBI

This study identifies cMet/HGFR as a modulator of early neuroinflammation in TBI, showing that its inhibition reduces microglial reactivity and improves recovery.

Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

This study shows that reducing neuronal nuclear calcium signaling after TBI increases microglial reactivity and synaptic loss, mediated by osteoprotegerin.

Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection

The paper identifies IL-13 and its receptor as neuronal synaptic proteins that enhance synaptic activity and neuroprotection in response to injury.

Shank2 expression identifies a subpopulation of glycinergic interneurons involved in nociception and altered in an autism mouse model

The paper identifies a subpopulation of glycinergic interneurons in the spinal cord regulated by Shank2, whose dysfunction contributes to pain hypersensitivity in ASD mouse models.