Author

Erik W. Thompson

Translational Research InstituteORCID 0000-0002-9723-4924Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Approach:statistical model· 2 Research Focus:trajectory inference· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Sugandha BhatiaiD· 3 shared Mohit Kumar JollyiD· 2 shared Paras JainiD· 2 shared Alka SaxenaiD· 1 shared Cameron W. EvansiD· 1 shared Clémentine Mercé· 1 shared Jason Thomas GeorgeiD· 1 shared Jessica J. KingiD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersSystems Biology

Sugandha BhatiaORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintDec 7, 2023

Cell-state transitions and frequency-dependent interactions among subpopulations together explain the dynamics of spontaneous epithelial-mesenchymal heterogeneity in breast cancer

Paras Jain, Ramanarayanan Kizhuttil, Madhav B Nair…·Mohit Kumar Jolly

The paper models the dynamics of E-M heterogeneity in breast cancer cells, finding that cell-state transitions, not growth differences, are essential for explaining observed population dynamics.

1 citation

humanbulk RNA-seq

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GenomicsbioRxivPreprintAug 21, 2023

Metastable Intermediates Identified in Epithelial to Mesenchymal Transition are Regulated by G-Quadruplex DNA Structures

Jessica J. King, Cameron W. Evans, Ulrich D. Kadolsky…·Nicole M. Smith

The paper introduces a new multiplexed single-cell sequencing method to identify metastable cell states during EMT and shows G-quadruplex DNA stabilization can inhibit EMT.

3 citations

humanscRNA-seq

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Systems BiologyBiomoleculesPeer-reviewedFeb 23, 2022

Population dynamics of epithelial-mesenchymal heterogeneity in cancer cells

Paras Jain, Sugandha Bhatia, Erik W. Thompson, Mohit Kumar Jolly

The paper models phenotypic switching in cancer cells to explain spontaneous epithelial-mesenchymal heterogeneity through stochastic SNAIL partitioning during cell division.

21 citations

humanbulk RNA-seq

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