Loss of Pigment Epithelium Derived Factor Sensitizes C57BL/6J Mice to Light-Induced Retinal Damage
Debresha A. Shelton, Jack T. Papania, Tatiana E. Getz, Jana T Sellers, Preston E. Giradot, Micah A. Chrenek, Hans E. Grossniklaus, Jeffrey H. Boatright, John M. Nickerson
This study shows that PEDF deficiency in mice increases light-induced retinal damage, with worsened visual function, retinal thinning, and Galectin-3 expression.
bioRxiv · Dec 4, 2024 · PreprintMolecular Biology