Jana T Sellers

Dietary serine protects the retinal pigmented epithelium by blunting reactive oxygen species in dry age-related macular degeneration

This study shows that dietary serine reduces ROS accumulation and improves retinal function in AMD by restoring mitochondrial function and GSH levels through PHGDH regulation.

Loss of Pigment Epithelium Derived Factor Sensitizes C57BL/6J Mice to Light-Induced Retinal Damage

This study shows that PEDF deficiency in mice increases light-induced retinal damage, with worsened visual function, retinal thinning, and Galectin-3 expression.

Oral supplementation with Nicotinamide Riboside treatment protects RGCs in DBA/2J mouse model

This study shows that oral Nicotinamide Riboside (NR) treatment protects retinal ganglion cells (RGCs) and optic nerve axons in DBA/2J mice, likely through increased retinal NAD+ levels, and also prevents iris depigmentation and delayed IOP elevation.

Systemic Treatment with Nicotinamide Riboside is Protective in Three Mouse Models of Retinal Degeneration

This study shows that systemic NR treatment protects against retinal degeneration in three mouse models by preserving retinal function and structure and increasing NAD+ levels.