John M. Nickerson

This study examines how treadmill exercise affects retinal vascular morphology, function, and immune factors in a mouse model of retinal degeneration, finding improved vascular health and immune response profiles in exercised mice.

The paper uses high-resolution 3D imaging to analyze RPE cell structure, revealing that apparent multinucleation often results from displaced nuclei and lateral membranes, not true fusion.

This study shows treadmill exercise reduces inflammation and alters miRNA expression in a light-induced retinal degeneration model, preserving retinal function and photoreceptor density.

This study shows that PEDF deficiency in mice increases light-induced retinal damage, with worsened visual function, retinal thinning, and Galectin-3 expression.

This study shows that oral Nicotinamide Riboside (NR) treatment protects retinal ganglion cells (RGCs) and optic nerve axons in DBA/2J mice, likely through increased retinal NAD+ levels, and also prevents iris depigmentation and delayed IOP elevation.

This study evaluates age-related changes in RPE structure and function in C57BL/6J mice, finding increased alpha-catenin expression and immune cell recruitment in aged mice.

The paper introduces MultiHeadGAN, a deep learning method for segmenting low contrast RPE cells in impaired flatmount images, achieving high segmentation accuracy.

This paper shows treadmill exercise increases retinal astrocyte complexity and BDNF interactions, protecting against light-induced retinal degeneration.

This study shows that systemic NR treatment protects against retinal degeneration in three mouse models by preserving retinal function and structure and increasing NAD+ levels.

This study investigates the protective effects of HIOC and TUDCA on retinal ganglion cell (RGC) death following optic nerve crush in mice, finding significant RGC survival in treated groups.