James P. Ropa

This paper introduces a competitive transplantation method using HLA-mismatched human hematopoietic stem cells in humanized mice to study repopulating capacity and track graft dynamics.

This study shows that local oxygen levels affect hematopoietic cell growth, metabolism, and potency, with low oxygen preserving less proliferative, stress-resistant cells.

This study shows that neuropeptide Y deficiency in the bone marrow drives hematopoietic stem and progenitor cell aging, and NPY supplementation can reverse age-related defects.