This paper introduces a competitive transplantation method using HLA-mismatched human hematopoietic stem cells in humanized mice to study repopulating capacity and track graft dynamics.

Stem Cell Research & Therapy · Oct 27, 2026Peer-reviewedCell Biology

Advanced Deep Learning Enables Prediction of Allogeneic Stem Cell Mobilization Success

Asif Adil, Jingyu Xiang, Nicola Piccirillo, Hillary G. Harris, Simona Sica, John F. DiPersio, Stephanie N. Hurwitz

This paper develops machine learning models to predict donor success in stem cell mobilization using clinical data, enabling early intervention and personalized strategies.

Bone Marrow Transplantation · Mar 17, 2026Peer-reviewedBioinformatics

Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations

Lucas Tricoli, Sunetra Sase, Julia Liao Hacker, Vi Pham, Maxwell Chappell, Laura Breda, Stephanie N. Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Matthew Hogenauer, Aoife M. Roche, , Stefano Rivella

This paper develops a novel lentiviral vector for gene therapy of MLD that achieves high ARSA activity with minimal genomic integrations, improving safety and efficacy in preclinical models.

Molecular Therapy — Nucleic Acids · Jan 25, 2025Peer-reviewedMolecular Biology