Rodrigo Orlandini de Castro

This study identifies a CHD4-CTCF regulatory axis that controls key developmental programs and transitions in male germ cells by regulating chromatin structure and gene expression.

The paper describes a method to efficiently isolate synchronized mouse spermatocytes for genome-wide chromatin analysis, demonstrating its use in ChIP-seq studies of meiotic chromatin binding sites.

This study shows that CHD4 is essential for neonatal spermatogonia survival and gonad development by regulating Dmrt1 and Plzf expression.

This study shows that PSMC3 is essential for spermatogonia niche establishment in mouse gametogenesis, leading to impaired gonad development and fertility.